Down Stream Process of Biopharmaceuticals
Recovery and purification of biosynthetic products, notably pharmaceuticals, from natural sources like animal or plant tissue or fermentation broth is referred to as downstream processing. This process also involves recovering salvageable parts and properly handling and disposing of waste. A pure and homogenous protein product is produced from biological materials, such as cells, tissue culture fluid, or plant tissues, through a sequence of steps known as downstream processing (DSP). Isolating, purifying, and concentrating the previously produced medicinal ingredient or other product from the intricate bulk matrix is the goal of downstream processing. Formulation processes may also be included in downstream processing, denoting the change from drug substance to drug product.
- Solid-Liquid Separation
- Release of Intracellular Products
- Concentration
- Purification by Chromatography and Formulation
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